[HTML][HTML] Systematic analysis of clemastine, a candidate apicomplexan parasite-selective tubulin-targeting agent
I Abbaali, DA Truong, SD Day, N Haro-Ramirez… - International journal of …, 2021 - mdpi.com
… resolved by SDS-PAGE for subsequent immunoblot analysis using a broadly cross-reacting
α-tubulin monoclonal antibody that recognizes both vertebrate and Toxoplasma tubulin. …
α-tubulin monoclonal antibody that recognizes both vertebrate and Toxoplasma tubulin. …
[PDF][PDF] Designed parasite-selective rhomboid inhibitors block invasion and clear blood-stage malaria
S Gandhi, RP Baker, S Cho, S Stanchev… - Cell chemical …, 2020 - cell.com
… potentially allowing structural analysis of GlpG to guide our attempt at PfROM4 inhibitor
development. We therefore solved and compared the tetrahedral complex structures between E. …
development. We therefore solved and compared the tetrahedral complex structures between E. …
[HTML][HTML] Network-driven analysis of human–Plasmodium falciparum interactome: processes for malaria drug discovery and extracting in silico targets
… and structural analysis; (4) gene mapping and enrichment … The identified genes, malaria
parasite selective variants, and … as hits for the monoclonal antibody category, pomalidomide for …
parasite selective variants, and … as hits for the monoclonal antibody category, pomalidomide for …
… Sites on TcPolβ by Protein Kinases TcCK1, TcCK2, TcAUK1, and TcPKC1 and Effect of Phorbol Ester on Activation by TcPKC of TcPolβ in Trypanosoma cruzi …
E Maldonado, P Canobra, M Oyarce, F Urbina… - Microorganisms, 2024 - mdpi.com
… By using a specific anti-phosphor Tyr monoclonal antibody, it was determined that TcCK1 …
a way that opens up the possibility of developing parasite-selective protein kinase inhibitors. …
a way that opens up the possibility of developing parasite-selective protein kinase inhibitors. …
From magic bullet to magic bomb: reductive bioactivation of antiparasitic agents
S Wittlin, P Mäser - ACS Infectious Diseases, 2021 - ACS Publications
… not preclude parasite-selective drug action. There are many cases where structural differences
… of the ozonides was investigated using monoclonal antibodies directed toward bicyclic …
… of the ozonides was investigated using monoclonal antibodies directed toward bicyclic …
Discovery of novel drugs for Chagas disease: is carbonic anhydrase a target for antiprotozoal drugs?
A Beatriz Vermelho, GC Rodrigues… - Expert Opinion on …, 2022 - Taylor & Francis
… However, sulfonamides and monoclonal antibodies targeting CAs are in advanced clinical
… Using virtual structure-based screening and validation by computational methodologies …
… Using virtual structure-based screening and validation by computational methodologies …
[HTML][HTML] Plasmodium vivax and human hexokinases share similar active sites but display distinct quaternary architectures
… Overall structure of PvHK To aid in the effort to develop parasite-selective HK inhibitors,
we sought to understand the structural differences between human and Plasmodium …
we sought to understand the structural differences between human and Plasmodium …
Structural-based Study to Identify the Repurposed Candidates Against Bacterial Infections
D Dey, A Kumar - Current Medicinal Chemistry, 2024 - ingentaconnect.com
… The drugs belonging to monoclonal antibodies, anti-cancer, anti-biotics, combination
dosage, hormonal therapies, radiopharmaceuticals and ophthalmic preparations, DNA/RNA …
dosage, hormonal therapies, radiopharmaceuticals and ophthalmic preparations, DNA/RNA …
[HTML][HTML] Activity of pyridyl-pyrazolone derivatives against Trypanosoma cruzi
DGJ Batista, LF de Almeida Fiuza, F Klupsch… - Experimental …, 2024 - Elsevier
… monoclonal antibodies targeting either PD-1 or PD-L1 to reinvigorate exhausted T cells in
the tumor microenvironment (Ai et al., 2020). Anti-PD-1 and anti-PD-L1 monoclonal antibodies …
the tumor microenvironment (Ai et al., 2020). Anti-PD-1 and anti-PD-L1 monoclonal antibodies …
Traditional medicine and natural products as antiparasitic agents
A Rezaeilaal, H Nasoori, HS Shamsnia… - Advances in …, 2024 - Elsevier
… discussion of alkaloids, just a few key subclasses and specific structures are mentioned
here. … An excellent parasite selective index was also revealed in the in vitro assays [98]. …
here. … An excellent parasite selective index was also revealed in the in vitro assays [98]. …